Many Rabs are substrates of LRRK2 (Rab3A/B/C, Rab3D, Rab8A, Rab8B, Rab10, Rab12, Rab29/RAB7L1, Rab35, and Rab43) [209], and all PD-related mutations enhance Rab phosphorylation [210]. Here, RAB8A is linked to Parkinson disease.