Thus, summarizing all of the above, it should be noted that DNases combine several mechanisms, giving an impact to the antimetastatic effect: (i) reducing the motility of tumor cells, thus affecting the rate of invasion, (ii) preventing the formation of a favorable tumor microenvironment due to the possible effect on NETs, (iii) decreasing the level of SINE/LINE elements and c-Myc fragments, thus reducing the level of transformation and malignization, and (iv) inducing the apoptosis of tumor cells in metastatic foci. The gene discussed is MYC; the disease is neoplasm.