B16 cells were implanted i.v.; starting from the fifth day, mice were treated i.n. by saline buffer (control), DNase I (2.5 mg/kg, or 100 U/mouse) or Pulmozyme® (5 mg/kg, or 100 U/mouse) two times per week on 5, 8, 12, 15, 19 and 22 days after tumor implantation (Figure 3A). The gene discussed is DNASE1; the disease is neoplasm.