DNASE1 and melanoma: The ability of Pulmozyme® and DNase I to induce apoptosis of B16 melanoma cells was investigated and depicted in Figure 1B. Pulmozyme® in the concentration of 0.5 × 103 U/mL induced apoptosis in 30–40% of cells for 24 h (10–15% of cells were detected in early apoptosis, 15–25% in late apoptosis), despite the fact that the toxic effect of Pulmozyme® at the same concentrations was insignificant.