Similarly, spinal cord astrocytes derived from induced pluripotent stem cells (iPSCs) of ALS patients with the C9orf72 mutation displayed a significant increase in SA-β-Gal expression and a reduction in the proliferation-related marker Ki-67 overtime, supporting the involvement of senescence in the disease and its age-dependent development [17]. Here, C9orf72 is linked to amyotrophic lateral sclerosis.