Studies in individuals with ALS have further supported the specific involvement of the SASP in disease development, as patients display significantly elevated levels of IL-6, IL-8, and nitrite in their blood serum [40] and increased IL-2, IL-10, IFN-γ, and TNF-α plasma concentrations [41] compared to healthy age-matched controls. This evidence concerns the gene TNF and amyotrophic lateral sclerosis.