In fact, in critically ill COVID-19 patients, IFN-I and INF-III levels and IFN-stimulated gene responses are lower compared with other respiratory viruses, while proinflammatory cytokines, including interleukin-2 (IL-2), IL-6, and tumor necrosis factor (TNF), are increased [60,61,62]. The gene discussed is IL6; the disease is COVID-19.