VWF and COVID-19: In addition, it was reported that the median activity of the VWF cleaving protease ADAMTS-13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) in COVID-19 patients was lower than the expected median of the normal reference range, and the VWF to ADAMTS-13 ratio was associated with COVID-19 disease severity [95].