The characteristic pathological hallmarks of Alzheimer’s disease (AD) are neurofibrillary tangles (NFTs) that consist of intracellular hyperphosphorylated tau [1], and senile plaques (SPs) formed by the aggregation of extracellular amyloid β peptide (Aβ) [2]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.