PRDM12 and neoplasm: In particular, PRDM12 was frequently mutated in a splice donor site in a region coding for the PR domain in different tumor types (breast cancer; colon adenocarcinoma; kidney renal clear cell carcinoma; lung adenocarcinoma; pancreatic adenocarcinoma; prostate adenocarcinoma; skin cutaneous melanoma; thyroid carcinoma; uterine corpus endometrial carcinoma) indicating this position as a possible mutational hotspot site (Figure 1) [25].