Initially, 10 different homozygous mutations in PRDM12 were identified in subjects from 11 families with a congenital insensitivity to pain (CIP), a type of hereditary sensory and autonomic neuropathy (HSAN), which is a clinically and genetically heterogeneous group of inherited neuropathies predominantly affecting peripheral sensory and autonomic neurons [32]. The gene discussed is PRDM12; the disease is hereditary sensory and autonomic neuropathy.