To examine the function of GPI-80 in tumors, this study investigated its expression levels in representative urinary cancer cell lines, (three prostate cancer cell lines (PC3, DU145, and LNCaP), two kidney cancer cell lines (A-704 and Caki-1), and four bladder cancer cell lines (HT1376, RT-4, SCaBER, and T-24)). This evidence concerns the gene VNN2 and urinary bladder cancer.