By analyzing the TCGA genomics, we also found that the gene alteration rates in the melanoma TCGA dataset were 12% for DDX60, 5% for CSNK1E, 2.8% for FGD1, 2.1% for GBP4, 4% for IFIH1, 1% for DOK1, and 0.7% for IRX3 (Figure 6c), and these alterations were not significantly correlated with mRNA expression. The gene discussed is GBP4; the disease is melanoma.