ACHE and neuroblastoma: Wu et al. ion-paired donepezil with docusate, ibuprofen, and unsaturated fatty acids, producing ILs that were thoroughly characterized regarding their structural and physicochemical properties, as well as in vitro antiproliferative action on human neuroblastoma cells, acetylcholinesterase (AchE) inhibitory activity, and ability to permeate through model blood–brain and skin barriers [142].