In the levels of IL-1β, the three groups of rabbits with induced dry eye showed a fold increase of 34.611 ± 35.999 in the dry eye group, 42.014 ± 27.068 in the dry eye + HPMC group, and 11.114 ± 9.537 in the dry eye + Artemia salina group that was statistically significant in comparison with the healthy rabbits (p < 0.05). The gene discussed is IL1B; the disease is Keratoconjunctivitis sicca.