Molecular mechanisms underlying meningioma progression are usually connected to aberrant signaling pathways such as PI3K-AKT-mTOR, Ras-Raf-MEK, Rac-PAK-JNK, TGFβ-SMAD, RB, p53, Hedgehog, Notch and canonical Wnt [3,4,5,6,7,8,9]. The gene discussed is AKT1; the disease is meningioma.