Interestingly, in the tumor samples, increased methylation of the majority of the ENPP2 CGs (cg00320790, cg01243251, cg02156680, cg02709432, cg07236691, cg09444531, cg14409958, cg20048037, cg20162626, cg23725583) (all p < 0.05) was noticed in women in relation to men. Here, ENPP2 is linked to neoplasm.