In order to study any relation of ENPP2 methylation to cancer aggressiveness, we compared cell lines from hepatocellular and prostate cancer presenting a more (SKHEP1 and PC3 respectively) or less (HEPG2 and LNCAP respectively) invasive phenotype, using the GSE71627 study dataset [33]. Here, ENPP2 is linked to Familial prostate cancer.