ENPP2 and cancer: In order to unravel aberrant ENPP2 methylation in cancer, we compared methylomes of malignant vs. respective benign tissues from 7 different cancer types, using 10 GEO datasets (GSE113017, GSE113019, GSE120878, GSE27130, GSE63704, GSE76938, GSE98534, GSE46306, GSE134772, GSE97686) (Table 1).