Nrf2 deficiency is known to enhance susceptibility to both ischemic and nephrotoxic acute kidney injury, as reflected in worsened renal function, histology, vascular permeability and survival in Nrf2-knockout mice compared with wild-type mice after IR, in addition to increasing proinflammatory cytokine and chemokine expression [136]. The gene discussed is NFE2L2; the disease is acute kidney injury.