Moreover, the triple transgenic AD (3xTg AD) model mice (name: B6; 129Psen1tm1Mpm Tg(APPSwe, TauP301L)), which carried the human APP KM670671NL, tau P301L, and PS1 M146V mutation, were also recrewed to examine whether the tau pathology was affected by BEOV. Here, PSEN1 is linked to Alzheimer disease.