Despite its reported oncogenic activity, miR-17-5p downregulation in resistant BRAF and MEK inhibitor melanoma cell lines could act as a tumor suppressor through a lack of post-transcriptional protein death ligand 1 (PD-L1) regulation and overactivation of the Wnt-β catenin AKT/PI3K pathway [57], which is known to modulate the melanoma microenvironment [2]. This evidence concerns the gene AKT1 and melanoma.