The scorpion toxin chlorotoxin triggered internalization of a cell-surface complex containing MMP2 and the colocalized chloride channel ClC-3, also disrupting glioma cell volume regulation [131], and reduced invasiveness by 34% in acutely dissociated glioma cells from human biopsy tissue, and by 55% in cultured glioma cell lines [106,139]. Here, CLCN3 is linked to glioma.