Mutations of anabolic signaling proteins phosphoinositide 3-kinase (PI3K), epidermal growth factor receptor (EGFR), and isocitrate dehydrogenase types 1 and 2 (IDH1, IDH2) have been widely detected in glioblastoma patient biopsy samples [21,22,23]. Here, PIK3CA is linked to glioblastoma.