DIO2 and hydrops fetalis: In addition, the T3 converting enzyme type II deiodinase (Dio2; PFDR = 0.022 and FC = 3.4) and the thyroid hormone precursor thyroglobulin (Tg; PFDR = 0.03 and FC = 2.1), the T3 converting enzyme and thyroid hormone precursor, respectively, were both up-regulated during development and in HF relative to week 20 sham mice.