Based on GO-term enrichment analysis, the DEGs up-regulated with HF were highly enriched for genes involved in biological processes: cell adhesion (GO:0007155; PFDR = 4.7 × 10−6) extracellular matrix organization (GO:0030198; PFDR = 2.99 × 10−5), collagen fibril organization (GO:0030199; PFDR = 6.76 × 10−5) and response to stress (GO:0006950; PFDR = 0.00361), including Col1a1, Col3a1, Postn, Wisp1 and Srfp2 (Table S3) and coding for proteins localized in the proteinaceous extracellular matrix (GO:0005578; PFDR = 6.26 × 10−19). The gene discussed is CCN4; the disease is hydrops fetalis.