The SUR1-TRPM4 channel interfaces with several other key secondary injury pathways [11], including those involved with cerebral edema (AQP4) [95], BBB integrity (matrix metalloproteinase-9 (MMP9), zona-occludens-1 (ZO-1)) [36,40,44,96], neuroinflammation (nitric oxide synthase-2 (NOS2), nuclear factor of activated T-cells (NFAT), calcineurin, calmodulin-dependent protein kinase II (CAMK-II) [36,40,45,92,97,98], and cell-death—including apoptotic pathways (Bcl-associated X protein (BAX), caspase-3; Table 1 and Figure 3). The gene discussed is NOS2; the disease is brain edema.