In a series of targeted investigations into the impact of ABCC8 and TRPM4 genetic variability on secondary injury after TBI in a single-center cohort of 385–485 patients with severe TBI, they identified several regionally clustered polymorphisms in both genes that were consistently associated with measures of intracranial hypertension, radiographic edema, and hemorrhage progression. This evidence concerns the gene TRPM4 and intracranial hypertension.