TRPM4 and ischemic stroke: SUR1-TRPM4 is not expressed in normal CNS tissue [6] but is upregulated de novo in different cells including astrocytes, neurons, endothelial cells, macrophages and microglia after forms of CNS injury including ischemic stroke [6,65,68], SAH [36,40], TBI [26], SCI [27,28], CNS metastases [41], and others [6,26,29,36,65,68,69,70].