In contrast, MLT supplementation reversed the SD-induced changes in colitis and inflammatory response along with an increase in MLT and butyrate; no significant difference was observed in fecal occult blood, body weight (p > 0.052), colon length (p > 0.099), colonic permeability (p > 0.335), histopathological score (p > 0.243), anti-inflammatory cytokines (IL-10 and IFN-γ, p > 0.283), proinflammatory cytokines (TNF-α and IL-17, p > 0.215), and enteritis sensitive protein Card9 (p > 0.220) among the SD + MLT, SD + Abs + MLT, and CON groups. Here, IFNG is linked to colitis.