Jo et al. showed that HOIP expression was elevated in activated B cell-like (ABC) diffuse large B cell lymphoma (DLBCL) and the LUBAC inhibitor suppressed the growth of lymphoma cells in the tumor transplantation model for human B cell lymphomas using a cell line derived from aCD19-cre-HOIP/MyD88LP mouse [46]. Here, RNF31 is linked to diffuse large B-cell lymphoma.