SCN5A and myotonic dystrophy type 1: The study by Poulin et al. used a normal iPSC cell line and two DM1-iPSC cell lines differentiated to cardiomyocyte lineage to identify several DM1 related splicing defects in DM1 iPSC derived cardiomyocytes, and the investigators also demonstrated abnormal ion channel functions by cellular electrophysiology studies, including changes in Nav1.5 gating and slower conduction veloicites [104].