TARDBP and proteostasis deficiencies: Interestingly, translational activation of CyclinD1 and TDP-43 mRNAs via Ataxin2-mediated polyadenylation in association with the Poly-A binding protein PAPD4 can induce TDP-43 proteinopathies, such as the Tau aggregation typical of FTLD, ALS, and AD [75,76].