GluA2-Q/R site editing was found to be reduced in the motor neurons of ALS patients, which enhances Ca2+ influx and thereby elevates calpain activation to cleave more TDP-43, which is associated with mis-localization and cytoplasmic aggregation of TDP-43, a hallmark of ALS [212]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.