Additionally, MMP-2 is also related to hyperalgesia after nociceptive stimulation and is also important for the activation of spinal microglial cells; however, MMP-2 activates IL-1β and stimulates microglial cells in the late stage of nociceptive stimulation to promote the development of advanced neuropathic pain [55], and its effect and occurrence are mostly related to the occurrence of late-stage neuropathic pain [55]. Here, IL1B is linked to neuropathic pain.