Additionally, hyperglycemia-induced expression of renal hedgehog interacting protein (Hhip) in glomerular endothelial cells may contribute to the fibrosis and apoptosis of such cells [61], and Hhip levels are also elevated in early DKD of diabetic mice and humans, even before the development of microalbuminuria [62]. The gene discussed is HHIP; the disease is Hyperglycemia.