Overall, a complex interplay between metabolic processes, epigenetic and nonepigenetic mechanisms, and transcriptional regulation is involved in the development and progression of DKD, and only in the last few years have potential drugs been identified, such as sodium-glucose cotransporter 2 (SGLT2) inhibitors that can act effectively against hypoglycemia and improve kidney outcomes [8,9]. Here, SLC5A2 is linked to diabetic kidney disease.