INS and diabetic kidney disease: Another factor involved in DKD is the cannabinoid receptor 1 (CB1R) [55], which activates the expression of the hormone receptor peroxisome proliferator-activated receptor γ2 (PPARγ2); subsequent binding of adipocyte-specific nuclear hormones to PPARγ2 then activates the transcription of genes involved in adipogenesis, including aP2, FGF1, FGF21, and CD36 [56], and promotes insulin sensitization in lipid metabolism [56].