It well known that p21WAF1 is transcribed at high levels after acute kidney injury [160], and inhibition of methyltransferase SUV39H1 expression has been found to attenuate hyperglycemia-induced fibronectin and p21WAF1 expression, and to accelerate hyperglycemia-induced cell hypertrophy [161]. The gene discussed is SUV39H1; the disease is Hyperglycemia.