CDX2 and diabetic kidney disease: Caudal-type homeobox transcription factor 2 (CDX2) can activate the transcription and expression of cystic fibrosis transmembrane conductance regulator (CFTR) to suppress Wnt signaling and prevent fibrosis [98], and an early study showed that expression of CDX2 improved renal tubular lesions in DKD patients and a mouse DKD model [98].