In AD, microglia have increased expression of complement receptors leading to upregulation of the NF-κB signaling pathway, Aβ-activated Fc receptors (which induces the expression of MIP-macrophage inflammatory protein-1α), and increased expression of scavenger receptors A-1 and B (SCARA and SCARB) [313,314]. This evidence concerns the gene NFKB1 and Alzheimer disease.