NLRP3 and graft versus host disease: In another study also conducted in patients transplanted through the JMDP, SNPs in the NLRP3 gene along with HLA mismatch were associated with acute and extensive GVHD in Japanese individuals who underwent HSCT for hematological malignancies, although those genetic variants did not correlate with survival outcomes, including TRM and overall survival [73], which was likely influenced by the considerable proportion of donor/recipient HLA mismatch in the cohort of patients included in this study.