NLRP3 and systemic lupus erythematosus: In particular, the variant rs10754558 (29940 G>C), located in the 3′-untranslated region (3′-UTR) of the NLRP3 gene has been shown to regulate NLRP3 expression [66] and has been associated with increased susceptibility to several inflammatory conditions [67], and a recent meta-analysis of eight studies (1764 cases and 1661 controls) found a significant association of the G allele of NLRP3 rs10754558 with type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus [68].