NLRP3 and endothelial dysfunction: Moreover, inflammation and pyroptosis triggered by NLRP3 inflammasome activation play a crucial role in aggravating oxidative stress and endothelial dysfunction [13], and accumulating evidence indicates that endothelial dysfunction is involved in various complications of HSCT such as VOD, transplant-associated thrombotic microangiopathy, and refractory acute GvHD [54].