Therapies that use anti-inflammatory drugs such as corticosteroids or NAIDs are very useful for inhibiting inflammation and angiogenesis in AMD, but because corticosteroids have many adverse effects, such as hypertension, insulin resistance, insomnia, irritability, purpura, skin thinning, cataracts, glaucoma, gastric ulceration, etc. [121], their usage is limited to combined treatments with photodynamic therapy or anti-VEGF drugs; furthermore, as NSAIDs’ long-term therapeutic efficacy is unclear, more studies are needed [122]. Here, VEGFA is linked to Insulin resistance.