Since cell motility has been shown to be an integral process in early lung cancer ontogeny, we studied the ability of EGCG to prevent NSCLC migration with respect to the expression of vinculin (Vnc) [24,25].Vnc is a well-known actin-binding protein involved in focal adhesion development acting as a tumor suppressor protein in cancer including in NSCLC [26]. The gene discussed is VCL; the disease is lung cancer.