p63 and p73 dysregulation contributes to tumor promotion both through p53-dependent and p53-independent mechanisms, including possible p53-indepdenent regulation of adhesive signaling, Notch activation, and Rb phosphorylation by p63 [98,99,100,101] and induction of Puma-mediated apoptosis by p73 [102]. This evidence concerns the gene BBC3 and neoplasm.