In addition, ubiquitination (LMO7 and HUWE1) and B cell differentiation (TPD52), the regulation of cellular innate and adaptive immunological pathways, and excessive expression of the proteins including Stomatin (a membrane protein in regulating ion transport; STOM), Annexin A4(ANXA4) and Annexin A1(ANXA1) found in extracellular vesicles are recognized in the tear film of primary SS patients [62]. The gene discussed is ANXA1; the disease is synovial sarcoma.