Vesicle associated molecular protein 8, Rab3D, aquaporin 5, β-fodrin, and angiotensin II type 2 receptor are translocated from apical membrane to cytoplasma or basal side of lacrimal gland epithelia, resulting in dysregulated production of tear component and loss of tear secretion leads to severe dry eye disease in Sjogren’s syndrome (SS). The gene discussed is AQP5; the disease is synovial sarcoma.