OPN4 and ocular hypertension: For example, a particular resilience has been documented for the melanopsin expressing ipRGCs against optic nerve injury [27,38,63,92,93,94], excitotoxicity induced by intravitreal injection of NMDA [64,95,96], acute [29] or chronic [28,65] ocular hypertension, or light induced phototoxicity [97].