TP53 and neoplasm: HDACs activity is essential for controlling gene expression by deacetylation of critical for tumor suppression and tumor development transcription factors such as tumor suppressor p53 (TP53, best known as p53) [14,15], forkhead box (FOX) proteins [16], nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) [17], and Myc-family proteins [18] (Figure 1).