MYST1–p65–SIRT1 complex represses apoptotic pathways enhancing cell proliferation and metastasis, while MYST1–p65–AR complex upregulates p21 protein expression leading to G2M phase arrest during cell cycle progression, resulting in the inhibition of PCa growth (Figure 4A) [17]. The gene discussed is SIRT1; the disease is posterior cortical atrophy.