In contrast to SIRT7, the ectopic expression of nuclear HDAC6 in NSCLC cells inhibits cancer invasiveness by the deacetylation of p65, which, in turn, decreases its binding to the matrix metalloproteinase-2 (MMP2) promoter and reduces MMP2 expression (Figure 4D) [89]. The gene discussed is MMP2; the disease is non-small cell lung carcinoma.