TP53 and primary cutaneous T-cell non-Hodgkin lymphoma: In cutaneous T-cell lymphomas (CTLC) treatment with HDIs, such as valproic acid (VPA), trichostatin A (TSA), and PCI-34051, enhances p53 acetylation and mRNA levels of p53-regulated genes Bcl-xl, NOXA, and PUMA that are involved in p53-mediated apoptosis, emphasizing the importance of p53 as a respond target to HDIs [56].