HDAC3 and breast cancer: In the BC LM2 cell line, the geminin, a DNA replication inhibitor, selectively tethers FOXO3a to HDAC3, which results in the deacetylation and inactivation of FOXO3a transcriptional activity leading to downregulation of the FOXO3a target Dicer, which is an RNase that suppresses metastasis [79].