MAPK3 and alcohol abuse: Oleoylethanolamide is known to induce anti-inflammatory effects via ERK1/2 inhibition in a model of LPS-stimulated THP-1 cells in vitro [53], while within the hippocampi of rats, in a study focusing on alcohol abuse, oleoylethanolamide has been shown to selectively increase p-ERK1/2 levels relative to the vehicle alone [53,71].