Similar to CRC, pancreatic ductal adenocarcinoma (PDAC) has also been shown to favor the PKM2 isoform over PKM1 secondary to PTBP1 upregulation and increased incidence of PTBP1 pre-mRNA binding, particularly in drug-resistant PDAC (DR-PDAC) [54]. The gene discussed is PKM; the disease is colorectal carcinoma.