TP53 and colorectal carcinoma: Xiong et al., in 2018, ran an analysis of RNA sequencing data from a cohort of patients with colorectal carcinoma (CRC) to identify differently expressed alternative splicing events (DEAS), finding a pattern of abnormal alternative splicing events in genes related to protein kinase activity, PI3K-Akt signaling, and p53 signaling, as well as a link between alternative splicing events and survival [46].