Among these, BRCA2, ATM, and PALB2 genes had higher mutation rates of ≥4% [10], while in mCRPC, 19.3% of aberrations in BRCA2, BRCA1, and ATM genes were found in bone or soft tissue tumor biopsies that were substantially more frequently compared to those in primary PC tissues [11]. This evidence concerns the gene BRCA2 and pachyonychia congenita.