PIK3R4 and hepatocellular carcinoma: In addition, expression of multiple other genes found in the autophagy KEGG pathway (hsa04140) were shown to be positively correlated with FOXO3 in HCC patients, highlighting the modest correlation observed by ATG5 (+0.62), UVRAG (+0.55), PIK3R4 (+0.51), ATG16L1 (+0.48), AMBRA1 (+0.47), ATG3 (+0.35), and RB1CC1 (+0.34) (Table 1) (Figure S1); altogether supporting an enhanced autophagic status.