Therefore, prior to exploring the involvement of FOXO3 in autophagy-mediated sorafenib resistance in vitro, we firmly set the basis regarding FOXO3 expression in HCC specimens, verified the association with survival-related prognosis, and ensured the correlation of FOXO3 with the expression of crucial autophagy genes in HCC patients. The gene discussed is FOXO3; the disease is hepatocellular carcinoma.