Pristane-induced lupus shows a clear type I interferon signature—similar to human lupus—mediated by the TLR7/MyD88 pathway and it was found that—in contrast to human SLE, where plasmacytoid dendritic cells have been identified as the main type I IFN-secreting cells—immature peritoneal Ly6Chigh monocytes adopt this function in pristane-induced lupus [40,41,42]. Here, MYD88 is linked to systemic lupus erythematosus.