UCP1 and obesity due to melanocortin 4 receptor deficiency: T3 is a known thermogenic hormone, leading to the activation of a non-shivering thermogenic program in BAT, which is responsible for the controlled dissipation of mitochondrial membrane potential (ΔΨ) as heat (due to the activation of the BAT-specific mitochondrial uncoupling protein 1-UCP1, also known as thermogenin), resulting in the burning of excess nutrients and thus leading to decreased obesity [10,11].