Although CRSwNP subjects with comorbid asthma have a higher recurrence rate after surgery than those without asthma and are regarded as a severe phenotype with high type 2 inflammation [9,158,170,171], there were weak correlations between levels of ITGB6(+)MP subtypes and eosinophil cationic protein (ECP) [37], indicating that the pattern of epithelial repair and EMT indicated by ITGB6(+)MP subtypes is distinct from that of type 2 inflammation. Here, ITGB6 is linked to chronic rhinosinusitis with nasal polyps.