A few studies have investigated the anti-inflammatory properties of GDNF in neurodegenerative disease models, such as PD, Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS; Table 4 and Figure 3) [26,27,28,30,31,32,33,175,176,177]. This evidence concerns the gene GDNF and neurodegenerative disease.