Moreover, panobinostat was able to prime NSCLC cell lines for the distinguishing effect of all-trans retinoic acid (ATRA) [108], and incorporating ATRA with the novel HDIs SL142 or SL325 repressed colony initiation, mediated apoptosis via Bax expression, and elevated caspase-3 activity in NSCLC cell lines [109]. The gene discussed is CASP3; the disease is non-small cell lung carcinoma.