In this context, our earlier study has shown that in patients, several nephropathies evolving toward fibrosis, such as acute interstitial nephritis, IgA nephropathy, and diabetic nephropathy, are also characterized by an imbalance of the IL-15/TGF-β ratio with weak intrarenal IL-15 expression and increased TGF-β expression [26]. The gene discussed is TGFB1; the disease is diabetic kidney disease.