FN1 and renal fibrosis: Moreover, IHC stainings reveal that fibronectin deposition was also reduced in both IL-15- and IL-15/IL-15Rα-treated UUO-kidneys when compared to vehicle-treated UUO-kidneys (Figure S2), demonstrating that IL-15 treatments reduce drastically the interstitial production of ECM proteins, thereby preventing UUO-induced renal fibrosis.