It has been observed that when osimertinib is administered to patients with EGFR mutant NSCLC who have previously received treatment with at least one line of therapy, a significantly shorter time to progression (PFS = 8.2 months) is observed [211] compared to the use of the drug in first lines of therapy (PFS = 18.9 months) [212]. Here, EGFR is linked to non-small cell lung carcinoma.