Mutations of some calcium trafficking genes, namely RYR1 and Calcium Voltage-Gated Channel Subunit Alpha1 S (CACNA1S), have been associated to severe conditions: anesthesia-induced malignant hyperthermia, central core disease [118], and multi-minicore disease [119] for the former and malignant hyperthermia and hypokalemic periodic paralysis for the latter. The gene discussed is CACNA1S; the disease is Central core disease.