PFKM and colorectal carcinoma: Further, the crucial role of TRAP1 in balancing OXPHOS/glycolysis was shown in CRC patient-derived spheroids and cell lines, where TRAP1 enhances GLUT1 expression, glucose uptake, and lactate production and downregulates OXPHOS via interaction with glycolytic enzyme PFK1 (phosphofructokinase-1) [77].