Similarly, a comparison of the mRNA levels of COX IV-1 and ATPase6 from patients with different stages of CRC have found that the decreased expression of COX IV-1 and ATPase6 correlates with increased ROS production during colorectal adenomatous polyp progression, thus pointing to the central role of COX IV-1 in the colorectal cell’s mitochondria energy production as they progress from polyps to carcinoma [63]. Here, MT-ATP6 is linked to carcinoma.