NFKB1 and cancer: Therefore, curcumin is a versatile agent in suppressing CSC features in cancer and various molecular pathways such as Wnt, Sonic, STAT3 and NF-κB, among others, are affected to reduce CSC markers such as CD44, ALDH and CD133 (Figure 5, Table 6) [331,332,333,334,335,336,337,338].