Moreover, in order to test the hypothesis that alterations in the equilibrium of Aβ levels between plasma and the brain can have a beneficial effect on the treatment of AD, Ordóñez-Gutiérrez and colleagues conducted a study with APP/PS1 transgenic mice (AD model), repeatedly injecting intraperitoneally liposomes composed of sphingomyelin, cholesterol, and cardiolipin [23]. The gene discussed is APP; the disease is Alzheimer disease.