This work identified peripheral blood methylation markers associated with incident T2D, five loci near the ATP-binding cassette sub-family G member 1 (ABCG1), sterol regulatory element-binding protein 1 (SREBF1), phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1), suppressor of cytokine signaling 3 (SOCS3) and thioredoxin-interacting protein (TXNIP) genes [117]. This evidence concerns the gene PHOSPHO1 and type 2 diabetes mellitus.