The relative risk of developing T2D per 1% increase in methylation at these marks was 1.09 for the cg06500161 (ABCG1) and 1.07 for the cg11024682 (SREBF1) but decreased by 6% for both the cg02650017 (PHOSPHO1) and the cg18181703 (SOCS3) and by 8% for the cg19693031 (TXNIP) [117]. This evidence concerns the gene TXNIP and type 2 diabetes mellitus.