INS and type 2 diabetes mellitus: Moreover, they identified the strongest T2D-related hypermethylated signal (chr18:56336501-56337000) in a region located at 2kb upstream of the TSS within the 5′ promoter of the mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) gene, involved in antigen receptor-mediated lymphocyte activation, in the development and function of B and T cells, and in insulin and glycemic pathways [116].