Among genes with altered expression and DNA-methylation changes in obese T2D individuals compared to non-obese controls, the protein kinase C epsilon (PRKCE), active BCR-related (ABR), and rho guanine nucleotide exchange factor (ARHGEF16) belonging to the nerve growth factor signaling and the C-terminal binding protein 1 (CTBP1), cyclin D1 (CCND1) and wingless-type MMTV integration site family, member 11 (WNT11) belonging to the Wnt signaling pathways emerged [109]. This evidence concerns the gene CTBP1 and type 2 diabetes mellitus.