TPCN1 and obesity due to melanocortin 4 receptor deficiency: These included known genes, such as the fatty acid synthase (FASN), retinoid X receptor alpha (RXRA), cytoplasmic polyadenylation element-binding protein 4 (CPEB4) and novel genes, such as solute carrier family 1 member 4 (SLC1A4), two-pore segment channel 1 (TPCN1) and strawberry notch homolog 2 (SBNO2), associated with diabetes and obesity traits [108].