Furthermore, the methylation of specific CpG sites on the TCF7L2 promoter in blood correlated with fasting glucose, total cholesterol and low-density lipoprotein cholesterol, shedding new light on the interplay between epigenetics and the TCF7L2 diabetes susceptibility gene in the development of T2D [115]. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.