TXA2 is involved in nephritis and kidney nephrotic syndrome by stimulating mesangial cells, causing them to contract, promoting proliferation, changing ion flow, and increasing the synthesis of fibronectin, laminin, tissue collagen plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1), and initiation of the synthesis of growth factors [15]. Here, SERPINE1 is linked to nephritis.