SLC17A7 and Alzheimer disease: Interestingly, while vGLUT1 levels are decreased in AD patients [88,89], similar to what we observed in aged-P301Ls, vGLUT1 is upregulated in aged and amnestic MCI patients [88,90], which may help to explain the observed age-related hippocampal hyperexcitability observed in patients [83,84].